Associate Professor · Department of Pharmaceutical Sciences · University of Navarra
Maite Solas Zubiaurre is Associate Professor at the Department of Pharmaceutical Sciences of the University of Navarra and Principal Investigator in the field of neurodegenerative diseases and brain energetics. Her research focuses on the molecular mechanisms linking Alzheimer’s disease, metabolism and astrocyte biology, with a particular interest in insulin resistance and energy dysfunction as drivers of neurodegeneration.
She obtained her PhD at the University of Navarra, including an international research stay at the Karolinska Institute (Sweden), where she investigated the role of stress and insulin resistance in Alzheimer’s disease. She later completed a postdoctoral fellowship at the Max Planck Institute for Metabolism Research (Germany) under the supervision of Prof. Jens Brüning, expanding her expertise in insulin signaling and energy metabolism.
Since establishing her independent research line in 2014, she has led multiple national and international competitive projects, including grants funded by the Spanish Ministry of Science, the Pasqual Maragall Foundation, NARSAD and the European Research Council (ERC Consolidator Grant). Her work has contributed to high-impact publications in journals such as Science Advances, Nature Communications and Glia.
Dr. Solas has authored more than 50 peer-reviewed publications, accumulating over 4,000 citations and an h-index of 30. She actively collaborates with national and international research groups in neuroscience and metabolism and regularly presents her work at international conferences including AAIC, FENS and SENC. In addition, she is committed to mentoring young researchers, science outreach and promoting women in neuroscience.
Blood-brain barrier (BBB) disruption and immune cell infiltration increase the pathological outcomes present in aging, neurodegenerative diseases, and…
View paper →Alzheimer's disease (AD), the leading neurodegenerative disorder linked to aging, emerges within a paradoxical metabolic landscape. Despite rising…
View paper →Sirtuin 2 (SIRT2), a NAD+-dependent deacetylase, has been implicated in aging and neurodegenerative diseases such as Alzheimer’s disease…
View paper →This editorial challenges the long‐held neuron‐centered view of brain metabolism, relying on ample evidence that it is a…
View paper →Glucose is the primary energy source for the brain, and its continuous supply is essential for neuronal function.…
View paper →Empty zein nanoparticles (NP) have been shown to lower glycemia in rats by stimulating the secretion of endogenous…
View paper →Bariatric surgery is effective for the treatment and remission of obesity and type 2 diabetes, but pharmacological approaches…
View paper →Astrocytes are considered an essential source of blood-borne glucose or its metabolites to neurons. Nonetheless, the necessity of…
View paper →Abstract One of the most biologically relevant functions of astrocytes within the CNS is the regulation of synaptic…
View paper →Alzheimer’s disease (AD) is a complex and multifactorial neurodegenerative disorder characterized by cognitive decline, memory loss, behavioral changes,…
View paper →In this study, the plausible role of trimethylamine N-oxide (TMAO), a microbiota metabolite, was investigated as a link…
View paper →Sirtuin 2 (SIRT2) has been proposed to have a central role on aging, inflammation, cancer and neurodegenerative diseases;…
View paper →c-Jun N-terminal kinases (JNKs) are a family of protein kinases activated by a myriad of stimuli consequently modulating…
View paper →c-Jun N-terminal kinase 3 (JNK3) is suggested to play a key role in neurodegenerative disorders, especially in Alzheimer’s…
View paper →The largest cell fraction of the human nervous system is composed by glial cells. These non-neuronal cells are…
View paper →Alzheimer’s disease (AD) is the main type of dementia and is a disease with a profound socioeconomic burden…
View paper →Obesity and aging are becoming increasingly prevalent across the globe. It has been established that aging is the…
View paper →It has been established that ageing is the major risk factor for cognitive deficiency and it is becoming…
View paper →The brain is one of the most energy-consuming organs in the body. Satisfying such energy demand requires compartmentalized,…
View paper →Even though the involvement of serotonin (5-hydroxytryptamine; 5-HT) and its receptors in Alzheimer's disease (AD) is widely accepted, data on…
View paper →Blood-Brain barrier (BBB) disruption is a hallmark of central nervous system (CNS) dysfunction, and oxidative stress is one…
View paper →Recent investigations have increased the interest on the connection between the microorganisms inhabiting the gut (gut microbiota) and…
View paper →The brain depends on glucose as a source of energy. This implies the presence of glucose transporters, being…
View paper →Trimethylamine N-oxide (TMAO) is a molecule generated from choline, betaine, and carnitine via gut microbial metabolism. The plasma…
View paper →A potential role of marine n-3 polyunsaturated fatty acids (ω-3 PUFAs) has been suggested in memory, learning, and…
View paper →Nimodipine may be of interest to treat behavioral alterations and memory deficits. However, its oral administration is hampered…
View paper →Tau is a microtubule-associated protein highly expressed in neurons with a chief role in microtubule dynamics and axonal…
View paper →Obesity prevalence is increasing steadily throughout the world's population in most countries and in parallel the prevalence of…
View paper →Alzheimer’s disease (AD) is characterized by the loss of synaptic contacts caused in part by cytoskeleton disruption. Adrenomedullin…
View paper →Lavender essential oil is traditionally used and approved by the European Medicines Agency (EMA) as herbal medicine to…
View paper →Alzheimer’s disease (AD) is the most common cause of dementia in elderly people. Because of the lack of…
View paper →Alzheimer's disease (AD) is characterized phenotypically by memory impairment, histologically by accumulation of pTau and β-amyloid peptide and…
View paper →Five pharmaceutical strategies are currently approved by the US FDA for the treatment of obesity: orlistat, lorcaserin, liraglutide,…
View paper →High-fat diet (HFD) feeding induces rapid reprogramming of systemic metabolism. Here, we demonstrate that HFD feeding of mice…
View paper →The concept of central insulin resistance and dysfunctional insulin signalling in sporadic Alzheimer's disease (AD) is now widely…
View paper →In the present work, the involvement of JNK in insulin signaling alterations and its role in glutamatergic deficits…
View paper →c-Jun N-terminal kinases (JNKs) are a family of protein kinases that play a central role in stress signaling…
View paper →Alzheimer’s disease (AD) is the most common form of dementia in the elderly. Research focused on identifying compounds…
View paper →It is believed that glucocorticoids control the proliferation of neural progenitor cells, and this process is highly involved…
View paper →During past decades, ever-increasing life expectancy, despite the development of a sedentary lifestyle and altered eating habits, has…
View paper →It is becoming evident that chronic exposure to stress not only might result in insulin resistance or cognitive…
View paper →The cannabinoid system seems to play an important role in various neurodegenerative diseases including Alzheimer's disease (AD). The relationship of cannabinoid receptors (CB1R and CB2R) to…
View paper →It is becoming evident that chronic exposure to glucocorticoids might not only result in insulin resistance or cognitive…
View paper →The objective of the present work was to study a purported involvement of stress in amyloid pathology through…
View paper →The objective of the present work was to study the effects of an early-life stress (maternal separation, MS)…
View paper →Recent evidence suggests that activity-regulated cytoskeleton associated protein (Arc) and brain-derived neurotrophic factor (BDNF) are key players in…
View paper →BACKGROUND AND PURPOSE Stress is believed to be associated with the development of neuropsychiatric disorders, including Alzheimer's disease (AD).…
View paper →The present work investigated the involvement of cortisol and its receptors, glucocorticoid receptor (GR) and mineralocorticoid receptor (MR),…
View paper →Previous studies have failed to reach consensus on insulin levels in cerebrospinal fluid of Alzheimer's disease (AD) patients…
View paper →A growing body of evidence supports the use of serotonin 5-HT6 receptor antagonists as a promising mechanism for treating…
View paper →Neurotransmitter system dysfunction and synapse loss have been recognized as hallmarks of Alzheimer's disease (AD). Our hypothesis is…
View paper →There is much interest in understanding the mechanisms responsible for interactions among stress, aging, memory and Alzheimer's disease.…
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