This project investigates how insulin resistance in the brain may link age-related diseases such as type 2 diabetes and Alzheimer’s disease. In particular, it focuses on the role of insulin receptors in astrocytes, key brain cells involved in supporting and protecting neuronal function.
Using experimental mouse models, the study will examine how the loss of these receptors affects brain glucose metabolism, blood-brain barrier integrity, cerebral blood flow, and cognitive performance. Advanced imaging techniques, metabolic analyses, and behavioural memory tests will be used throughout the research.
The ultimate goal is to better understand the connection between aging, metabolism, and cognitive decline, helping to identify new strategies for the prevention and treatment of neurodegenerative diseases.