Science

Publications

Peer-reviewed research from the SOLAS Lab team.

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2025

Astrocytes as Metabolic Sensors Orchestrating Energy‐Driven Brain Vulnerability in Alzheimer’s Disease

Leyre Sánchez de Muniain, Paula Escalada, María J. Ramírez, Maite Solas

Journal of Neurochemistry · 6 October 2025

Alzheimer's disease (AD), the leading neurodegenerative disorder linked to aging, emerges within a paradoxical metabolic landscape. Despite rising cellular energy demands due to accumulated damage and stress, overall energy expenditure…

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2023

Trimethylamine N-oxide as a mediator linking peripheral to central inflammation: an in vitro study

Manuel H Janeiro, Maite Solas, Josune Orbe, Jose A Rodríguez, Leyre Sanchez de Muniain, Paula Escalada, Ping K Yip, Maria J Ramirez

MDPI - International Journal of Molecular Sciences · 16 December 2023

In this study, the plausible role of trimethylamine N-oxide (TMAO), a microbiota metabolite, was investigated as a link between peripheral inflammation and the inflammation of the central nervous system using…

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