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2025

Astrocytes as Metabolic Sensors Orchestrating Energy‐Driven Brain Vulnerability in Alzheimer’s Disease

Leyre Sánchez de Muniain, Paula Escalada, María J. Ramírez, Maite Solas

Journal of Neurochemistry · 6 October 2025

Alzheimer's disease (AD), the leading neurodegenerative disorder linked to aging, emerges within a paradoxical metabolic landscape. Despite rising cellular energy demands due to accumulated damage and stress, overall energy expenditure…

2024

Essential role of astrocytes in learning and memory

Paula Escalada, Amaia Ezkurdia, María Javier Ramírez, Maite Solas

MDPI - International Journal of Molecular Sciences · 5 February 2024

Abstract One of the most biologically relevant functions of astrocytes within the CNS is the regulation of synaptic transmission, i.e., the physiological basis for information transmission between neurons. Changes in…

2023

Trimethylamine N-oxide as a mediator linking peripheral to central inflammation: an in vitro study

Manuel H Janeiro, Maite Solas, Josune Orbe, Jose A Rodríguez, Leyre Sanchez de Muniain, Paula Escalada, Ping K Yip, Maria J Ramirez

MDPI - International Journal of Molecular Sciences · 16 December 2023

In this study, the plausible role of trimethylamine N-oxide (TMAO), a microbiota metabolite, was investigated as a link between peripheral inflammation and the inflammation of the central nervous system using…